intravenous amiodarone versus digoxin in atrial fibrillation rate control; a clinical trial
Authors
abstract
introduction: treatment of rapid ventricular response arterial fibrillation (rapid af) varies depending on the decision of the in-charge physician, condition of the patient, availability of the drug, and the treatment protocol of the hospital. the present study was designed aiming to compare iv digoxin and amiodarone in controlling the heart rate of patients presenting to emergency department with rapid af and relative contraindication for first line drug in this regard. method: in the present clinical trial, patients presented to the ed with rapid af and relative contraindication for calcium channel blockers and beta-blockers were treated with either iv amiodarone or iv digoxin and compared regarding success rate and complication using spss version 22. p < 0.05 was considered as statistically significant. results: 84 patients were randomly allocated to either amiodarone or digoxin treatment groups of 42 (53.6% male). the mean age of the studied patients was 61.8 ± 11.14 years (38 - 79). no significant difference was present regarding baseline characteristics. the rate of treatment failure was 21.4% (9 cases) in amiodarone and 59.5% (25 cases) in digoxin groups (p < 0.001). the mean onset of action was 56.66 ± 39.52 minutes (10 - 180) in amiodarone receivers and 135.38 ± 110.41 minutes (25 - 540) in digoxin group (p < 0.001). none of the patients showed any adverse outcomes of hypotension, bradycardia, and rhythm control. conclusion: based on the findings of the present study, rapid af patients with relative contraindication for calcium channel blockers or beta-blockers who had received amiodarone experienced both higher (about 2 times) treatment success and a more rapid (about 2.5 times) response compared to those who received iv digoxin.
similar resources
Intravenous Amiodarone versus Digoxin in Atrial Fibrillation Rate Control; a Clinical Trial
INTRODUCTION Treatment of rapid ventricular response arterial fibrillation (rapid AF) varies depending on the decision of the in-charge physician, condition of the patient, availability of the drug, and the treatment protocol of the hospital. The present study was designed aiming to compare IV digoxin and amiodarone in controlling the heart rate of patients presenting to emergency department wi...
full textRate versus rhythm control in atrial fibrillation.
OBJECTIVE To determine whether rate control is a viable initial treatment approach in persistent atrial fibrillation (AF) through the evaluation of recently completed trials comparing rate and rhythm control. DATA SOURCES Biomedical literature was obtained through MEDLINE (1966-December 2003) and the Iowa database. STUDY SELECTION AND DATA EXTRACTION Articles identified from the biomedical ...
full textAmiodarone versus sotalol for atrial fibrillation.
BACKGROUND The optimal pharmacologic means to restore and maintain sinus rhythm in patients with atrial fibrillation remains controversial. METHODS In this double-blind, placebo-controlled trial, we randomly assigned 665 patients who were receiving anticoagulants and had persistent atrial fibrillation to receive amiodarone (267 patients), sotalol (261 patients), or placebo (137 patients) and ...
full textBeta-blockers versus digoxin to control ventricular rate during atrial fibrillation.
Ezekowitz et al. (1) recently reported lack of benefit of angiotensin-converting enzyme (ACE) inhibitors on mortality in patients with chronic heart failure (CHF) in whom estimated creatinine clearance was below 60 ml/min, as opposed to a beneficial effect in those with creatinine clearance above 60 ml/min. The researchers attribute this lack of benefit to a possible interaction between aspirin...
full textIntravenous Methylprednisolone, a Possible Cause of the Atrial Fibrillation
We are presenting a case illustrating atrial fibrillation (AF) following the use of methylprednisolone in a patient with pelvic and femur fracture. A 48- year- old man with no significant past medical history, was admitted to the emergency department after injury in a car accident. He suffered a multiple bone fracture with chief complaints of pain and shortness of breath. He was transfer...
full textMy Resources
Save resource for easier access later
Journal title:
emergency journalجلد ۵، شماره ۱، صفحات ۲۹-۰
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023